The chain of custody of the body is hopelessly broken. We know nothing about its integrity over almost 400 years before the 20th century.
"there are traits compatible with Jewish origin" ... The DNA-driven results are “almost absolutely reliable" ... Columbus died in Valladolid, Spain, in 1506 but had wished to be buried on the island of Hispaniola ... His remains were taken there in 1542, then at least some of them moved to Cuba in 1795 and then to Seville in 1898."
Story here.
